P-selectin antibody patent

Author: fosf

August undefined, 2024

WebThe RB40.34 monoclonal antibody speciﬁcally binds to mouse P-selectin (CD62P), a 140 kDa protein which is expressed ... P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002; 99(3):946-956. ... BD Biosciences will not be held responsible for a patent infringement or other violations that may occur with the use of our products ... WebThe invention relates to the use of an anti-P-selectin antibody or binding fragment thereof, suitably crizanlizumab or a binding fragment thereof in the treatment of myelofibrosis (MF). The invention also relates to a pharmaceutical combination comprising a) an anti-P-Selectin antibody and b) at least one further therapeutic agent, preferably ruxolitinib or a …

Characterization of Two Anti-P-Selectin Monoclonal Antibodies …

WebP-Selectin (CD62P), previously termed PADGEM or GMP-140, is a single chain glycoprotein of 140 kDa expressed in platelets and endothelial cells. In platelets, P-selectin is stored in … WebMarkers of platelet membrane proteins were identified using antibodies against CD47 and P-selectin. 2.4. Encapsulation Efficiency [email protected] was subjected to centrifuge at 20,000× g for 40 min to separate the free CCM from the encapsulated drug. The amount of free CCM in the supernatant was determined spectrophotometrically at 426 nm. bring your own phone wireless plans

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

WebNov 5, 2024 · Methods: For both mAbs, we assessed: P-selectin affinity (surface plasmon resonance [SPR]/Biacore assay); inhibition of adhesion of P-selectin-expressing cells to P … WebFeb 6, 2024 · While IL-1β antibody can reduce neutrophil infiltration and matrix metalloproteinase-2 activity [11], IL-1α antibody blunts the activation of endothelial cells and the expression of adhesion molecules in the BBB thereby reducing penumbral macrophage content and neurotoxic mediators, such as MMPs [12]. WebP-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins … bring your own phone to tracfone

FITC anti-human/mouse Cutaneous Lymphocyte Antigen (CLA) Antibody

The clinical impact of glycobiology: targeting selectins

WebAnti-P-selectin antibodies and methods of using the same to treat inflammatory diseases Abstract The invention features antibodies, e.g., chimeric and humanized antibodies, that recognize... WebP-Selectin Antibody (CTB201) is an IgG 1 κ mouse monoclonal P-Selectin antibody (also designated CD62 antibody, SELP antibody, selectin P antibody) suitable for the detection of the P-Selectin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. P-Selectin Antibody (CTB201) is available as both the non-conjugated anti-P-Selectin … can your fingers shrinkWebMar 23, 2024 · 1. Delivered a preclinical candidate for inflammation (US Patent 2014039308 - issued) This work was published in Nature (doi: … can your fingernails tell your health

"WebJan 18, 2002 · Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions … " - P-selectin antibody patent

P-selectin antibody patent

BV421 Rat Anti-Mouse CD62P BD OptiBuild™

WebOct 15, 2024 · The glycoprotein (GP) P-selectin, a member of the C-type lectin family, 1 is rapidly translocated from α-granules of platelets and Weibel-Palade bodies of endothelial cells to the cell surface on stimulation. 2 3 It mediates rolling of platelets and neutrophils on activated endothelial cells 4 5 as well as interactions of activated platelets with … WebMar 24, 2024 · Lack of P-selectin in mice induces the development of a lupus-like syndrome and patients with cutaneous lupus have reduced P-selectin expression in skin vessels. ... of PSGL-1 and low levels of PSGL-1 in neutrophils from SLE patients associated with the presence of anti-dsDNA antibodies, clinical lung involvement, Raynaud's phenomenon, …

Did you know?

WebProduct Specific Information. Description: The Psel.KO2.3 monoclonal antibody reacts with mouse CD62P (also known as P-selectin and GMP-140), a 140-kDa cell adhesion molecule that can be induced on … WebCD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. It is expressed …

WebCD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. It is expressed … WebWO-9821591-A1 chemical patent summary. This application requires Javascript. Please turn on Javascript in order to use this application.

WebThe P-selectin antibodies can be used to treat inflammatory and thrombotic conditions, e.g., sickle cell disease, pain crisis associated with sickle cell disease, deep vein thrombosis, asthma,... WebDec 3, 2016 · The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle …

WebCD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. It is expressed on activated platelets, megakaryocytes, and endothelial cells. CD62P is primarily stored in secretory α-granules in platelets and Weibel-Palade bodies in endothelial cells ...

WebNov 5, 2024 · Crizanlizumab, a first-in-class humanized anti-P-selectin IgG2 mAb, is approved in >40 countries to reduce/prevent VOCs in SCD patients aged ≥16 yrs. Inclacumab, a fully human anti-P-selectin IgG4 mAb, is in clinical development for SCD. bring your own phone tracfoneWebCLA is a carbohydrate epitope of sialic acid and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1), a surface glycoprotein expressed on the majority of peripheral blood leukocytes. CLA is a ligand for E-selectin, P-selectin, and L-selectin. It plays a role in memory lymphocyte homing, tethering, and rolling. Product Details bring your own pot calgaryWebWestern Blot analysis of P-Selectin (CD62P) in various cell lines using a P-Selectin (CD62P) Polyclonal antibody ( Product # PA5-120169) at a dilution of 1:1,000. 25 µg of lysate or protein were loaded into each lane. A blocking buffer of 3% nonfat dry milk in TBST was used. An HRP conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody was ... can your fingernails show your healthWebCompounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs or derivatives of these groups, such that sialic acid and fucose are separated by a linker that permits … bring your own spoon by saad z hossainWebJun 1, 2024 · Introduction: Previously, in a murine model of blunt thoracic trauma, we provided evidence of primary pulmonary thrombosis associated with increased expression of the cell adhesion molecule, P-selectin. In this study, mice are treated with P-selectin blocking antibody after injury to investigate the clinical viability of this antibody for the … bring your own phone us cellularWebNational Center for Biotechnology Information bring your own picnic winelandsWebCompounds, compositions, and methods for treating and/or preventing at least one disease, disorder, and/or condition N associated with E-selectin, galectin-3, and/or CXCR4 chemoki bring your own skates to guptills