Chromium slope factor
WebIn 2008, EPA’s Office of Pesticide Programs identified a cancer slope factor of 0.791 per milligrams hexavalent chromium per kilogram body weight per day (mg/kg-d)-1 based … WebIf the risk is to be set at 1 in 1 million, what is the acceptable chronic daily intake for hexavalent chromium, a compound with a low dose cancer risk and a slope factor of 42 kg−d/mg ? 4.20∗10∧7 2.38⋅10∧ −5 4.20⋅10∧ −5 2.38⋅10∧ −8 Previous question
Chromium slope factor
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WebCR = Cancer Risk, D = Age-Specific Dose (mg/kg/day), CSF = Cancer Slope Factor ( (mg/kg/day) -1 ), AAC = EF-adjusted Air Concentration (µg/m 3 ), IUR = Inhalation Unit … WebCalculation of Cancer Slope Factor (CSF) •M and F mouse data modeld •F mice poorly fit by benchmark dose suite of dose‐response models •Based on the POD •Lower 95% CI on the dose corresponding to the 10% tumor response in ... •Chromium in drinking water: sources, metabolism, and cancer risks. ...
WebNational Center for Biotechnology Information WebThe slope factor is the result of application of a low-dose extrapolation procedure and is presented as the risk per (mg/kg)/day. The unit risk is the quantitative estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m air breathed. The third form in which risk is presented is a drinking water or air
WebAn oral cancer slope factor of 0.79 (mg/kg/day)"1 was used to estimate risk. Although exposure to children is not expected based on the current use patterns, because limited data suggest that older children may have increased sensitivity to chromium VI, the Agency applied Age Dependent Adjustment Factors (ADAF) to the potency factor. WebJan 1, 2024 · C S F Where, CSF is the cancer slope factor and is defined as the risk generated by a lifetime average amount of one mg/kg/day of carcinogen chemical and is …
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Web•Slope should increase after the excceedanceof the reduction capacity •Investigated using NTP data for various tissues at various time points •Mouse kidney, liver glandular and … how does migration affect our economyWebrecommended standard is based on the EPA’s cancer slope factor for hexavalent chromium. DHS recommends that the preventive action limit for hexavalent chromium be set at 10% of the enforcement standard because hexavalent chromium has been shown to have carcinogenic, mutagenic, teratogenic, and interactive effects. Health Effects how does migration affect a country\u0027s economyWebThe carcinogenicity of chromium compounds is reviewed with specific attention to the gaps in knowledge for risk estimation and research needs. The most important problems at present are whether trivalent chromium compounds cause cancer, and whether there is a difference in cancer causing effects bet … The carcinogenicity of chromium photo of harry and meghan\\u0027s daughterWebSep 3, 1998 · Carcinogenicity by the oral route of exposure cannot be determined and is classified as Group D. Under the proposed guidelines (EPA, 1996), Cr (VI) would be … photo of harry and meghanWebApr 11, 2024 · The roughness factor (RF) is another important parameter that defines catalyst surface roughness and can influence observed catalytic properties. ... Comparison of the OER performances in an alkaline electrolyte (overpotential at 10 mA cm −2 current density, and Tafel slope) of recently published chromium-based catalysts with our work. … photo of harley davidson motorcycleWebChromium-hexavalent CAS Number 18540-29-9 Synonym Chromium VI; Cr6; Chrom 6; Hexavalent chromium; Soluble hexavalent chromium compounds Occurrence/Use … photo of harry truman in masonicWebIncremental lifetime cancer risk is obtained using the Cancer Slope Factor (CSF), which is the risk produced by a lifetime average dose of 1 mgkg -1 BWday -1 and is contaminant specific [ 16]. It was worked out for As, Cd and Pb using respective slope factors of 1.5, 6.3 and 0.0085 (mgkg -1 day -1) -1 in equation 2. (2) how does migration help animals survive